Sphagneticola trilobata is listed in the IUCN's “List of the world's 100 worst invasive species”. It is spread by people as an ornamental or groundcover that is planted in gardens, and then it is spread into surrounding areas by dumping of garden waste. It spreads vegetatively, not by seed. It rapidly forms a dense ground cover, crowding away and preventing other plant species from regenerating. This species is widely available as an ornamental and is therefore likely to spread further.
It is a noxious weed in agricultural land, along roadsides urban waste places and other disturbed sites. It is also invasive along streams, canals, along the borders of mangrove swamps and in coastal vegetation.
It is widespread as an invasive species on the Pacific Islands, Hong Kong, South Africa, Australia, Indonesia, and Sri Lanka.